Is truth itself natural? This is an important question for both those working on truth and those working on naturalism. For theorists of truth, answering the question of whether truth is natural will tell us more about the nature of truth (or lack of it), and the relations between truth and other properties of interest. For those working on naturalism, answering this question is of paramount importance to those who wish to have truth as part of the natural order. In (...) this paper, we focus primarily on the kinds of theories of truth that occupy the central positions in current debates about truth, namely correspondence theories, deflationary theories, epistemic theories, and pluralist theories, and aim to discern the extent to which truth is a natural property on each view. (shrink)

We get cut-free sequent calculi for the interpolable propositional intermediate logics by translating suitable duplication-free tableau calculi developed within a semantical framework. From this point of view, the paper also provides semantical proofs of the admissibility of the cut-rule for appropriate cut-free sequent calculi.

Is truth itself natural? This is an important question for both those working on truth and those working on naturalism. For theorists of truth, answering the question of whether truth is natural will tell us more about the nature of truth (or lack of it), and the relations between truth and other properties of interest. For those working on naturalism who wish to have truth as part of the natural order, answering this question is of paramount importance. In this chapter, (...) we focus primarily on the kinds of theory of truth that occupy the central positions in current debates about truth, namely correspondence theories, deflationary theories, epistemic theories, and pluralist theories, and aim to discern the extent to which truth is a natural property on each view. (shrink)

Can someone who suspends judgement about a certain proposition <p> be in a relational state of disagreement with someone who believes <p> as well as with some- one who disbelieves <p>? This paper argues for an af- firmative answer. It develops an account of the notions of suspended judgement and disagreement that explains how and why the suspender is in a relational state of disagreement with both the believer and the disbeliever about the very same proposition <p>. More specifically, the (...) paper first provides a characterisation of the norma- tive profile associated with the state of suspended judge- ment in terms of the set of normative commitments that it engenders in the context of inquiry. It then provides a characterisation of the notion of disagreement in terms the incompatibility between the sets of normative com- mitments characteristic of the three states in question— belief, disbelief, and suspension. (shrink)

The main objective of this study was to analyze the influence of tactical and situational variables on offensive sequences during elite European handball matches. A sample of 55 games and 5.857 offensive sequences from the European Handball Federation Champions League, the selected teams were classified as the top eight teams in the league, were analyzed using X2 and logistic regression analyses. Results indicated that positional attacks [odds ratio = 0.34; 95% CI: 0.28–0.42; p < 0.001] and fast attacks decreased the (...) probability of success for an offensive sequence by 66% and 54% when compared with counterattacks. Offensive sequences that start in the attacking zone seem to be less effective than those that start from a situation of “ball in center.” Additionally, offensive sequences that finished in the defensive zone of the observed team were 3.19 times more effective than those that ended before the 9 m zone. We concluded that compared with offensive sequences where the shot is performed from the 9 m zone, the chances of an offensive sequence ending successfully are 3.65, 3.60, and 2.21 times higher, for offensive sequences where the shot is performed from 9 m, 6 m, and the defensive zone, respectively. On the other hand, many variables seem to impact the performance of handball teams. Nevertheless, a significant challenge remains, and more research needs to be conducted to analyze the obstacles that teams need to overcome while attacking in the most effective way possible. (shrink)

… philosophy must be a practice as much as it is a theory.Leah Kalmanson, Cross-Cultural Existentialism, p. 1In the face of the sheer quantity of life's uncertainties, Leah Kalmanson's Cross-Cultural Existentialism provides more than a novel take on existential theory ; following the mantra of European existentialists that "philosophies are meant to be lived," Cross-Cultural Existentialism introduces the reader to a series of practices central to the Ruist tradition required to make philosophy "a concrete attitude, a way of life". Kalmanson's (...) turn to the East Asian tradition is largely motivated by her assessment that the... (shrink)

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐based “active genetic” elements developed in 2015 bypassed the fundamental rules of traditional genetics. Inherited in a super‐Mendelian fashion, such selfish genetic entities offered a variety of potential applications including: gene‐drives to disseminate gene cassettes carrying desired traits throughout insect populations to control disease vectors or pest species, allelic drives biasing inheritance of preferred allelic variants, neutralizing genetic elements to delete and replace or to halt the spread of gene‐drives, split‐drives with the core constituent (...) Cas9 endonuclease and guide RNA (gRNA) components inserted at separate genomic locations to accelerate assembly of complex arrays of genetic traits or to gain genetic entry into novel organisms (vertebrates, plants, bacteria), and interhomolog based copying systems in somatic cells to develop tools for treating inherited or infectious diseases. Here, we summarize the substantial advances that have been made on all of these fronts and look forward to the next phase of this rapidly expanding and impactful field. (shrink)

On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild‐type male, all her offspring displayed the same recessive yellow phenotype. Further analysis of other such yellow females revealed that the construct causing the mutation was converting the opposing chromosome with 95% efficiency. These simple results, seen also in (...) mosquitoes and yeast, open the door to a new era of genetics wherein the laws of traditional Mendelian inheritance can be bypassed for a broad variety of purposes. Here, we consider the implications of this fundamentally new form of “active genetics,” its applications for gene drives, reversal and amplification strategies, its potential for contributing to cell and gene therapy strategies, and ethical/biosafety considerations associated with such active genetic elements. (shrink)

Documediality indicates the allegiance between the constitutive power of documents and the mobilizing power of the media. The chapter proposes to treat documediality as the ending point of a great historical transformation whose previous phases have been capitalism and mediality. Capitalism in the strict sense corresponds to the economic era of production, and to the political era of liberalism. When populism prevails over liberalism, and communication has the upper hand over production, we enter the phase of mediality. Finally, documediality corresponds (...) to a third phase, characterized by recording: that is, by the use of a huge apparatus, namely the Web, which has the essential feature of keeping track of any interaction. This chapter highlights the key features of documediality in comparison to those of capitalism and mediality. (shrink)

Although our idea of sequential input being a key to cerebellar function was taken seriously by most commentators, there were also objections, based in part on experimental evidence that seems to contradict our intuitions and in part on commentators' preferences for different schemes. Several were suspicious of experiments (performed on slices of cerebellar tissue) that may have severed some of the synaptic connections, particularly the inhibitory ones. It is our feeling that a modi-fication of our theory that could satisfy most (...) critics would not have to be very radical. (shrink)

How does a Muslim jurist think the law and how, accordingly, he judges a fact? Using Alice in Wonderland as hermeneutical device to explore the logic of fiqh, this article identifies a divergence between Western and Islamic legal thinking in the application of abduction as key form of inference in the law of Islam. In particular, looking at the fact/law relation in symbolic terms, the article highlights how, while a dichotomy between fact and law characterizes Western legal thinking, fiqh upholds (...) a connection between the “real” and the “right”, where the effort in understanding sharī‘ah postulates the actualization of the “rule” in God’s creation. Thus, if sharī‘ahpre-scribes the Law, not only is the rule discovered through the sources, but the right has to be justified through a verdict de-scribing the fact, for the law to be validly stated for the given situation. In this sense, abduction as explanatory “hypothesis” and “inference to the best explanation” of sharī‘ah provides an account for the probabilistic nature of fiqh, its ramification through verdicts, as well as for the epistemic and narrative function of the tradition as core aspects of the logic of Islamic law. At the same time, doubts can be raised about the compatibility between this logic and the deductive logic of modern state law, as a sub-product of Western legal thinking. (shrink)

On the basis of a critique of the notion of collective intentionality employed by John Searle to explain social reality, the article argues Searle’s constitutive rule that, for social objects “X counts as Y in C” raises more problems than it solves. Searle was perfectly right to say that Derrida’s formula “there is nothing outside the text” is false. But we can vindicate (and emend) Derrida by saying “ there is nothing social outside the text”: social objects are identified with (...) the inscrbed acts that give rise to them. (shrink)

Un’originale interpretazione di Lettera a una professoressa che, a mezzo secolo dalla sua uscita, si presta a una rilettura in chiave sociologica. Concetti come “capitale culturale”, “ideologia delle doti”, “violenza simbolica”, “habitus”, “codici linguistici”, ne costituiscono di fatto la cornice teorica.Depurando il priore di Barbiana dalle incrostazioni ideologiche che si sono andate sommando nel tempo, fino a falsarlo sublimandolo in una icona buona per tutti gli utilizzi, anche politici, sottolineandone l’eccezionale statura ma anche i, sia pur pochi, limiti, se ne (...) ottiene una rappresentazione più vicina alla realtà, inquadrata nell’ambito della Chiesa fiorentina del suo tempo. (shrink)

Reflection Principles are commonly thought to produce only strong axioms of infinity consistent with V = L. It would be desirable to have some notion of strong reflection to remedy this, and we have proposed Global Reflection Principles based on a somewhat Cantorian view of the universe. Such principles justify the kind of cardinals needed for, inter alia , Woodin’s Ω-Logic.

According to the form of logical pluralism elaborated by Beall and Restall there is more than one relation of logical consequence. Since they take the relation of logical consequence to reside at the very heart of a logical system, different relations of logical consequence yield different logics. In this paper, we are especially interested in understanding what are the consequences of endorsing Beall and Restall’s version of logical pluralism vis-à-vis the normative guidance that logic is taken to provide to reasoners. (...) In particular, the aim of this paper is threefold. First, in Sections 2 and 3, we offer an exegesis of Beall and Restall’s logical pluralism as a thesis of semantic indeterminacy of our concept of logical consequence – i.e. understood as indeterminacy logical pluralism. Second, in Sections 4 and 5, we elaborate and critically scrutinize three models of semantic indeterminacy that we think are fit to capture Beall and Restall’s indeterminacy logical pluralism. Third, in Section 6, following Beall and Restall’s assumption that the notion of logical consequence has normative significance for deductive reasoning, we raise a series of normative problems for indeterminacy logical pluralism. The overall conclusion that we aim to establish is that Beall and Restall’s indeterminate logical pluralism cannot offer an adequate account of the normative guidance that logic is taken to provide us with in ordinary contexts of reasoning. (shrink)

In order to understand the system wherein human resource management practices are determined by the interactions of a complex system of actors, it is necessary to have a conceptual framework of analysis. In this respect, the works of scholars concerning stakeholder theory opened new perspectives in management theory. An organisation is understood as being part of a politico-economic system of stakeholders who interact and influence management practices. Each stakeholder tries to optimise and protect his interests, 61-75). The framework of stakeholder (...) analysis enables escape from a purely instrumental approach to HRM, and avoids reducing our understanding of conflicts within companies to mere antagonism between employees and their employers. It enables us to point out the existence of other stakeholders in the relationship. Notably, it allows for the incorporation into management theory of actors from the sphere of politics as well as their dependent administrations. All these actors are considered to be stakeholders who define the legal framework of firm management and guarantee the application of these laws. (shrink)

Against the consensus that Aristotle in the "Poetics" sets out to give tragedy a role in exercising or improving the mature citizen's moral sensibilities, I argue that his aim is rather to analyse what makes a work of literature successful in its own terms, and in particular how a tragic drama can achieve the effect of suspense. The proper pleasure of tragedy is produced by the plotting and eventual dispelling of the play's suspense. Aristotle claims that poetry 'says what is (...) universal' not in order to suggest that poetry achieves anything of the effect of philosophy, but to explain how in creating his plots the poet takes into consideration what, in general, could be expected to happen. Chapter 4 of the "Poetics" is not a theory of mimesis but an analysis of the lowest common denominator of the pleasure we take in fictions. The inevitability or likelihood by which events in the tragic plot are to be connected has an aesthetic rather than a moral function. Doing away with the irrationality of chance and increasing the human intelligibility of the action is not its point; the point is to furnish the plot with the second half of the formula for successful suspense: that events in the plot should happen 'against expectation because of one another'. The first half of the formula is examined under the rubric of peripety or reversal. The formula as a whole describes the pivotal moment when the pieces of the plot suddenly fit with a configuration that only in retrospect can we see to have been falling into place all along. Pity and fear are the emotions on which Aristotle focusses because they are the emotions engaged by the tightening-towards-release of literary suspense. And the pleasure of catharsis is the pleasure of that release. (shrink)

IntroductionParkinson’s disease patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.MethodsWe have conducted a systematic review according to PRISMA guidelines (...) through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.ResultsSixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompassed in the studies cited in this review is 3677, not including the meta-analyses.ConclusionCognitive function in PD patients can deteriorate, in most cases mildly, but still impactful to the quality of life. The strongest evidence is present for deterioration in verbal fluency, while inconclusive evidence is still present for executive function, memory, attention and processing speed. Global cognition does not appear to be significantly impacted by DBS, especially if cognitive screening is performed prior to the procedure, as lower baseline cognitive function is connected to poor outcomes. Further randomized controlled studies are required to increase the level of evidence, especially in the case of globus pallidus internus DBS, pedunculopontine nucleus DBS, and the ventral intermediate nucleus of thalamus DBS, and more long-term studies are required for all respective targets. (shrink)

Starting from macroscopic and microscopic facts of cerebellar histology, we propose a new functional interpretation that may elucidate the role of the cerebellum in movement control. The idea is that the cerebellum is a large collection of individual lines (Eccles's : Eccles et al. 1967a) that respond specifically to certain sequences of events in the input and in turn produce sequences of signals in the output. We believe that the sequence-in/sequence-out mode of operation is as typical for the cerebellar cortex (...) as the transformation of sets into sets of active neurons is typical for the cerebral cortex, and that both the histological differences between the two and their reciprocal functional interactions become understandable in the light of this dichotomy. The response of Purkinje cells to sequences of stimuli in the mossy fiber system was shown experimentally by Heck on surviving slices of rat and guinea pig cerebellum. Sequential activation of a row of eleven stimulating electrodes in the granular layer, imitating a of the stimuli along the folium, produces a powerful volley in the parallel fibers that strongly excites Purkinje cells, as evidenced by intracellular recording. The volley, or has maximal amplitude when the stimulus moves toward the recording site at the speed of conduction in parallel fibers, and much smaller amplitudes for lower or higher The succession of stimuli has no effect when they in the opposite direction. Synchronous activation of the stimulus electrodes also had hardly any effect. We believe that the sequences of mossy fiber activation that normally produce this effect in the intact cerebellum are a combination of motor planning relayed to the cerebellum by the cerebral cortex, and information about ongoing movement, reaching the cerebellum from the spinal cord. The output elicited by the specific sequence to which a is tuned may well be a succession of well timed inhibitory volleys the motor sequences so as to adapt them to the complicated requirements of the physics of a multijointed system. (shrink)

In the 80's Pierangelo Miglioli, starting from motivations in the framework of Abstract Data Types and Program Synthesis, introduced semiconstructive theories, a family of large subsystems of classical theories that guarantee the computability of functions and predicates represented by suitable formulas. In general, the above computability results are guaranteed by algorithms based on a recursive enumeration of the theorems of the whole system. In this paper we present a family of semiconstructive systems, we call uniformly semiconstructive, that provide computational procedures (...) only involving formulas with bounded complexity. We present several examples of uniformly semiconstructive systems containing Harrop theories, induction principles and some well-known predicate intermediate principles. Among these, we give an account of semiconstructive and uniformly semiconstructive systems which lie between Intuitionistic and Classical Arithmetic and we discuss their constructive incompatibility. (shrink)

In the 80's Pierangelo Miglioli, starting from motivations in the framework of Abstract Data Types and Program Synthesis, introduced semiconstructive theories, a family of “large subsystems” of classical theories that guarantee the computability of functions and predicates represented by suitable formulas. In general, the above computability results are guaranteed by algorithms based on a recursive enumeration of the theorems of the whole system. In this paper we present a family of semiconstructive systems, we call uniformly semiconstructive, that provide computational procedures (...) only involving formulas with bounded complexity. We present several examples of uniformly semiconstructive systems containing Harrop theories, induction principles and some well-known predicate intermediate principles. Among these, we give an account of semiconstructive and uniformly semiconstructive systems which lie between Intuitionistic and Classical Arithmetic and we discuss their constructive incompatibility. (shrink)